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半胱氨酸蛋白酶抑制剂超家族成员作为一种肿瘤标志物,对于组织细胞具有重要的调节与保护功能,对于肿瘤的生长、浸润和转移起重要作用,同时在肿瘤的诊断和预后方面也有意义。但是,研究表明半胱氨酸蛋白酶抑制剂在不同类别的肿瘤组织中的表达情况各不相同,对于预后的提示作用也因具体类别而定。其具体作用机制尚不明确。现就半胱氨酸蛋白酶抑制剂与恶性肿瘤的关系予以综述。
As a tumor marker, cysteine protease inhibitor superfamily members play an important regulatory and protective role in tissue cells and play an important role in tumor growth, invasion and metastasis, and also have a great significance in tumor diagnosis and prognosis . However, studies have shown that the expression of cystatin in different types of tumor tissue vary, and the prognostic impact is also dependent on the specific category. Its specific mechanism of action is not yet clear. Now the relationship between cystatin and malignant tumors are reviewed.