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神经元的淘汰性死亡早已被认为是个体正常发育中一个必不可少的过程。在脊椎动物，这种现象在神经支配细胞的过程中能得到很好的展示，并且很容易地以一段时间内净细胞数的减少来监测。在发育过程中，有限的神经营养素调控着神经元的存活。这些神经营养素是神经生长因子（NGF）
The knock-out of neurons has long been considered an essential part of normal development in an individual. In vertebrates, this phenomenon is well demonstrated in the process of innervation of the cells and is easily monitored by the reduction of the number of neutrophils over a period of time. During development, limited neurotrophins regulate the survival of neurons. These neurotrophins are nerve growth factor (NGF)