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目的:分析妇幼保健院药品不良反应报告的相关因素,为安全用药提供参考。方法:选择2014年4月—2016年4月间上报的345例药品不良反应报告,采用回顾性分析法,分析引起药品不良反应患者年龄以及涉及的药物类别、给药途径、累及器官等因素。结果:345例药品不良反应报告中,年龄段在18~40岁患者占41.45%显著高于其他年龄段患者;药物类别中抗感染药物占36.52%显著高于其他类别药物;心血管系统药物、神经系统药物构成比分别占13.91%和10.14%,仅次于抗感染药物;给药途径中,静脉滴注占55.65%显著高于其他给药途径;口服给药占26.38%仅次于静脉滴注;累及消化系统占56.52%显著高于其他脏器和系统,累及心血管系统占24.93%仅次于消化系统。结论:对药品不良反应报告予以全面分析,医院药品不良反应的发生存在一定规律与特征,可为临床合理用药提供有效指导,从而提高治疗安全性。
Objective: To analyze the related factors of adverse drug reaction reports in maternal and child health care hospitals, and provide reference for safe drug use. Methods: A total of 345 adverse drug reactions reported in April 2014-April 2016 were retrospectively analyzed. The age, drug category, route of administration and organ involvement were also analyzed. Results: In 345 cases of adverse drug reactions reports, the age group of patients aged 18-40 years accounted for 41.45% of patients was significantly higher than other age groups; drug classes accounted for 36.52% of anti-infective drugs was significantly higher than other categories of drugs; cardiovascular system drugs, The ratio of the drugs in the nervous system accounted for 13.91% and 10.14% respectively, second only to the anti-infective drugs. Among the routes of administration, intravenous drip accounted for 55.65%, significantly higher than other routes of administration; oral administration accounted for 26.38%, second only to intravenous drip Note; involving the digestive system accounted for 56.52% significantly higher than other organs and systems, involving the cardiovascular system accounted for 24.93% second only to the digestive system. Conclusion: A comprehensive analysis of reports of adverse drug reactions, the occurrence of adverse drug reactions in hospitals there are certain rules and characteristics of clinical rational use of drugs can provide effective guidance to improve the safety of treatment.