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目的探讨强直性脊柱炎(AS)患者血清中TNF-α、IFN-r、IL-4和IL-2的变化水平。方法选取来自某院在2009年10月～2012年1月住院的强直性脊柱炎患者共计85名,在相同时间纳入同样样本的健康对照85例,并且按照性别和年龄进行匹配。采用ELISA方法来检测AS患者和健康对照血清中的TNF-α、IFN-r、IL-4和IL-2。结果 AS患者和对照组比较,两组之间结果比较,IFN-r、IL-4与IL-2在AS组中明显高于对照组,差异有统计学意义(P﹤0.05)。AS活动期患者和AS非活动期患者比较,IFN-r在活动期AS组中明显高于对照组,差异有统计学意义(P﹤0.05)。结论血清中的TNF-α、IFN-r、IL-4和IL-2在强直性脊柱炎的发病机制中可能起到作用。
Objective To investigate the changes of serum TNF-α, IFN-γ, IL-4 and IL-2 levels in patients with ankylosing spondylitis (AS). METHODS: A total of 85 patients with ankylosing spondylitis hospitalized in a hospital from October 2009 to January 2012 were enrolled, and 85 healthy controls were enrolled in the same sample at the same time and matched according to sex and age. ELISA method was used to detect TNF-α, IFN-γ, IL-4 and IL-2 in serum of AS patients and healthy controls. Results Compared with the control group, the levels of IFN-γ, IL-4 and IL-2 in AS group were significantly higher than those in control group (P <0.05). Compared with inactive AS patients, the activity of IFN-γ in active AS group was significantly higher than that in control group, with significant difference (P <0.05). Conclusion Serum TNF-α, IFN-γ, IL-4 and IL-2 may play an important role in the pathogenesis of ankylosing spondylitis.