The Gravity Recovery and Climate Experiment(GRACE) has been measuring temporal and spatial variations of mass redistribution within the Earth system since2002. As large earthquakes cause significant mass changes on and under the Earth’s surface,GRACE provides a new means from space to observe mass redistribution due to earthquake deformations. GRACE serves as a good complement to other earthquake measurements because of its extensive spatial coverage and being free from terrestrial restriction. During its over 10 years mission,GRACE has successfully detected seismic gravitational changes of several giant earthquakes,which include the 2004 Sumatra–Andaman earthquake,2010 Maule(Chile) earthquake,and 2011 Tohoku-Oki(Japan) earthquake. In this review,we describe by examples how to process GRACE timevariable gravity data to retrieve seismic signals,and summarize the results of recent studies that apply GRACE observations to detect co- and post-seismic signals and constrain fault slip models and viscous lithospheric structures. We also discuss major problems and give an outlook in this field of GRACE application. The Gravity Recovery and Climate Experiment (GRACE) has been measuring temporal and spatial variations of mass redistribution within the Earth System since 2002. As large earthquakes cause significant mass changes on and under the Earth’s surface, GRACE provides a new means from space to observe mass redistribution due to earthquake deformations. of its extensive spatial coverage and being free from terrestrial restrictions. During its over 10 years mission, GRACE serves as a good complement to other earthquake measurements because of its extensive complement coverage 2004 Sumatra-Andaman earthquake, 2010 Maule (Chile) earthquake, and 2011 Tohoku-Oki (Japan) earthquake. In this review, we describe by examples how to process GRACE time variable gravity data to retrieve seismic signals, and summarize the results of recent studies that apply GRACE observations to detect co- and post-seismic signals and constrain fault slip mode ls and viscous lithospheric structures. We also discuss major problems and give an outlook in this field of GRACE application.