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目的 探讨食管鳞癌和不典型增生的端粒酶活性 ,同时研究端粒酶活性与癌的分化、浸润、转移的关系。方法 应用显微切割 TRAP 银染法对 4 5例食管鳞癌组织、癌旁非典型增生上皮及切缘的正常粘膜上皮进行定点端粒酶活性的检测。结果 食管正常粘膜上皮的端粒酶活性阳性率为 5 % (2 / 40 ) ,非典型增生上皮为 79 3% (2 3/ 2 9) ,癌组织为 82 2 %(37/ 4 5 )。非典型增生上皮的端粒酶活性明显高于正常上皮 ,差异有高度显著性 (P <0 0 1)。 2 8例有淋巴结转移者的癌组织中有 2 6例可检测到端粒酶活性 ,阳性率为 92 2 % ,明显高于无淋巴结转移者 (6 4 7% ,11/ 17) ,差异有显著性 (P <0 0 5 )。不同分化程度的癌组织其端粒酶活性差异均无显著性 (P >0 0 5 )。结论 食管鳞癌及其癌前病变端粒酶活性均明显增高。癌组织端粒酶活性与淋巴结转移有关 ,而与癌的分化程度无关
Objective To investigate the telomerase activity of esophageal squamous cell carcinoma and atypical hyperplasia, and to study the relationship between telomerase activity and the differentiation, invasion and metastasis of esophageal squamous cell carcinoma. Methods Microdissection TRAP silver staining was used to detect the telomerase activity in 45 cases of esophageal squamous cell carcinoma, adjacent atypical hyperplastic epithelium and normal mucosal epithelium of the margin. Results The positive rate of telomerase activity in normal esophageal mucosa epithelium was 5% (2/40), that of atypical hyperplasia epithelium was 79 3% (2 3/29) and that of cancerous tissue was 82 2% (37/45). The telomerase activity of atypical hyperplastic epithelium was significantly higher than that of normal epithelium (P <0.01). The positive rate of telomerase activity was detectable in 26 of 26 cases with lymph node metastasis (92.2%), significantly higher than those without lymph node metastasis (64.7%, 11/17) Significance (P <0 05). There was no significant difference in telomerase activity between cancer tissues with different degree of differentiation (P> 0.05). Conclusion The telomerase activity of esophageal squamous cell carcinoma and its precancerous lesions were significantly increased. Cancer tissue telomerase activity and lymph node metastasis, but not with the degree of cancer differentiation