在最近十年里,关于再生障碍性贫血(AA)骨髓衰竭病理生理的主要机理,从临床和实验观察出现了明显的分歧。临床观察是:病毒感染,某些药物,妊娠及免疫抑制能导致骨髓功能改变是事实,病毒引起的AA不同于药物引起和原发性再障。无论是上述什么原因引起的AA,经免疫抑制治疗后,可能使骨髓出现缓解,但在给免疫抑制治疗的第二个疗程时,无效者可转变为有效;而第一疗程有效的病人,如果复发,再给免疫抑制剂不一定有效,故不能用对免疫抑制治疗是否有效来区别疾病的类型。从培养的实验观察,也明显地出现相互矛盾的概念。用造血培养可识别有免疫能力的细胞和它们的可溶性产物,有足够的证据表明.T 细胞不能单独 In the last decade, major differences in the pathophysiology of aplastic anemia (AA) bone marrow failure have been observed clinically and experimentally. Clinical observations are: viral infection, certain drugs, pregnancy and immunosuppression can lead to changes in bone marrow function is the fact that the virus caused by AA is different from the drug-induced and primary aplastic anemia. Regardless of the cause of the above AA, immunosuppressive therapy may cause bone marrow remission, but in the second course of immunosuppressive therapy, ineffective can be converted to effective; and the first course of treatment effective in patients, if Recurrence, given immunosuppressive agents may not be effective, it can not be used in immunosuppressive therapy is effective to distinguish the type of disease. From the experimental observation of cultivation, there are also obvious contradictory concepts. There is sufficient evidence that hematopoietic cells that recognize immunocompetent cells and their soluble products show that T cells can not be treated alone