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由于Se—Se键相对活泼,对外部氧化和还原环境敏感,双硒聚合物在药物控释系统有广泛的应用.采用双硒二醇,异佛尔酮二异氰酸酯和低分子壳聚糖为原料制备出了两亲性的双硒聚合物.这种共聚物能够在水中发生自组装现象,形成稳定的以PU为核,壳聚糖为壳的球形纳米聚集体,粒径约为130 nm.并探索了该聚集体在氧化还原条件下的响应性,发现不管在弱氧化还是弱还原环境下,这种双硒聚合物都能发生Se—Se键断裂,使得装载在聚集体中的正电荷药物盐酸阿霉素达到控制释放的效果.
Because Se-Se bond is relatively active and sensitive to external oxidation and reduction environment, the double selenium polymer has been widely used in drug controlled release system.Using selenium diol, isophorone diisocyanate and low molecular weight chitosan as raw materials Amphiphilic double selenium polymer was prepared, which could self-assemble in water to form a stable spherical nano aggregate with PU as the core and chitosan as the shell with a particle size of about 130 nm. And explored the reactivity of the aggregates under redox conditions. It was found that the selenium-selenide polymers were cleaved by Se-Se bonds in both weakly oxidized and weakly reduced environments, so that the positive charge Drug doxorubicin hydrochloride to achieve the effect of controlled release.