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长期以来认为柳酸盐对肝脏不具毒性,即使大量给药,也只能引起肝脂肪浸润.早在1955年Nydick等曾注意到急性风湿热患者的肝酶升高与服用阿斯匹林有关,但并未引起重视.近十年发现这类药物无论对动物和人体均会导致肝损害:在家兔可以引起肝脂肪变性;大鼠每天投予40Dmg/kg水杨酸钠,可引起肝损害;人类口服2g或更少的阿斯匹林或柳酸盐,血液浓度超过250μg/ml时,对代谢异常的人体,可以导致肝炎,尤以阿斯匹林更为常见.
It has long been believed that the salts of salicylate are not toxic to the liver and can only cause hepatic steatosis even in large doses as early as 1955 when Nydick et al. Noted that elevated liver enzymes in patients with acute rheumatic fever were associated with taking aspirin, But did not pay attention to the past decade found that these drugs both in animals and humans will cause liver damage: in rabbits can cause hepatic steatosis; rats daily administration of 40Dmg / kg of sodium salicylate can cause liver damage ; Human oral 2g or less of aspirin or salicylate, the blood concentration of more than 250μg / ml, the metabolic abnormalities in humans, can lead to hepatitis, especially aspirin is more common.