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目的 探讨镁盐对急性心肌梗死 (AMI)溶栓后心律失常的治疗效果。方法 对 2 9例发病 12h内的急性心肌梗死患者随机分为治疗组和对照组。对照组病例入院后立即口服巴米尔 ,给予尿激酶溶栓治疗。此后每日常规口服巴米尔及硝酸甘油 ,腹壁皮下注射低分子肝素 ,10d一疗程。治疗组在对照组用药基础上 ,每日予 2 5 %硫酸镁 2 0ml加入 2 5 0ml极化液中静脉滴注 ,10d一疗程。分别观察心律失常、左心室功能改变、镁盐副反应以及住院病死率。结果 治疗组室性和房性心律失常发生率大大低于对照组 (P <0 .0 1) ,左室功能改善显著优于对照组 (P <0 .0 5 ) ,住院病死率明显少于对照组 (P <0 .0 5 ) ,治疗组无一例出现镁盐副反应。结论 镁盐能够有效地控制急性心肌梗死溶栓后心律失常的发生率及病死率
Objective To investigate the therapeutic effect of magnesium salt on arrhythmia after thrombolytic therapy of acute myocardial infarction (AMI). Methods 29 cases of acute myocardial infarction within 12 hours after onset were randomly divided into treatment group and control group. Patients in the control group were given oral Bamir immediately after admission and given urokinase thrombolysis. Since then daily routine oral Bamir and nitroglycerin, abdominal subcutaneous injection of low molecular weight heparin, 10d a course of treatment. The treatment group in the control group on the basis of medication daily to 25% magnesium sulfate 20ml added 250ml polarization solution intravenous infusion, 10d a course of treatment. Arrhythmia, changes in left ventricular function, side effects of magnesium and in-hospital mortality were observed. Results The incidence of ventricular and atrial arrhythmia in the treatment group was significantly lower than that in the control group (P0.01), and the improvement of left ventricular function was significantly better than that of the control group (P0.05). The in-hospital mortality rate was significantly less than In the control group (P <0.05), no side effects of magnesium salt occurred in the treatment group. Conclusion Magnesium salt can effectively control the incidence of arrhythmia and mortality after thrombolysis in acute myocardial infarction