目的探讨血小板内皮细胞黏附分子-1(PECAM-1)对2型糖尿病(T2DM)患者病情判断的价值。方法将19例T2DM患者分为A组(空腹血糖>10mmol/L,11例)和B组(空腹血糖7.10～10mmol/L,8例);另16例健康人为对照组(C组)。用ELISA法检测血清PECAM-1,同时检测糖化血红蛋白(HbA1c)和血糖(BG)。结果 A组的PECAM-1和HbA1c均高于C组(P<0.01)。A组PECAM-1与BG水平呈显著正相关(r=0.912,P<0.01),B组PECAM-1与HbA1c水平呈显著正相关(r=0.743,P<0.05)。结论 T2DM患者血清PECAM-1的高表达与高糖状态有关,可能是糖尿病血管并发症发生因素之一。 Objective To investigate the value of platelet-derived endothelial cell adhesion molecule-1 (PECAM-1) in the diagnosis of type 2 diabetes mellitus (T2DM). Methods Twenty-nine patients with T2DM were divided into group A (fasting blood glucose> 10mmol / L, n = 11) and group B (fasting blood glucose 7.10 ~ 10mmol / L, n = 8). Serum PECAM-1 was detected by ELISA and HbA1c and BG were measured simultaneously. Results The PECAM-1 and HbA1c in group A were higher than those in group C (P <0.01). There was a significant positive correlation between PECAM-1 and BG levels in group A (r = 0.912, P <0.01). There was a significant positive correlation between PECAM-1 and HbA1c levels in group B (r = 0.743, P <0.05). Conclusion The high expression of PECAM-1 in T2DM patients is associated with high glucose status, which may be one of the causes of diabetic vascular complications.