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本文通过实验性胃癌模型的建立,观察脾脏及Tuftsin的免疫功能对肿瘤发生的影响。 大鼠随机分为切脾组、切脾后注射Tuftsin组、模拟切脾组。术后第8周起各组大鼠连续自由饮取t50mg/L浓度的MNNG溶液共32周,同时对一组切脾动物开始注射Tultsin。结果提示脾脏在肿瘤免疫中有双重作用。脾脏具有一定的防止瘤前病变及抗早期肿瘤的作用;对于进展期肿瘤,脾脏介入了肿瘤引起的机体免疫抑制状态的形成过程,有促肿瘤生长作用。脾脏特异的因子Tuftsin,可增加组织局部炎症反应从而发挥其抗肿瘤的作用,同时也提示胃粘膜慢性炎症与胃癌发生并无直接联系。作者提出了在脾外伤和胃癌手术时作保留脾脏手术的具体意见,并认为Tuftsin如能用于临床,将是肿瘤生物学治疗的一个新的途径。
This article through the establishment of experimental gastric cancer model to observe the spleen and Tuftsin immune function on tumor occurrence. Rats were randomly divided into splenectomy group, Tuftsin group injected after splenectomy, and simulated spleen group. From the 8th week after operation, rats in each group continuously drank MNNG solution at a concentration of t50mg/L for 32 weeks. At the same time, Tultsin was injected into a group of splenic animals. The results suggest that the spleen has a dual role in tumor immunity. The spleen has a certain role in preventing precancerous lesions and resistance to early stage tumors; for advanced tumors, the spleen is involved in the formation of the body’s immunosuppressed state caused by tumors, which promotes tumor growth. Tuftsin, a spleen specific factor, can increase the local inflammatory response and exert its anti-tumor effect. It also suggests that the chronic inflammation of the gastric mucosa is not directly related to the occurrence of gastric cancer. The authors put forward specific suggestions for spleen preservation during splenic trauma and gastric cancer surgery, and believe that Tuftsin, if used in clinical practice, will be a new approach to tumor biological therapy.