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细胞凋亡与早期胚胎发育的关系密切,是导致胚胎发育停滞和辅助生殖技术(ART)失败的主要原因。抗凋亡因子在促进早期胚胎发育、提高胚胎质量和ART成功率等方面具有重要意义。综述细胞凋亡的分子调控机制及其诱导因素,以及调控凋亡基因表达的因子、生长因子、抗氧化剂、1-磷酸鞘氨醇、瘦素、前列环素、骨桥蛋白和热休克蛋白等几种重要的抗凋亡因子在促进早期胚胎发育方面作用机制的研究进展。
Apoptosis is closely related to early embryonic development, leading to the failure of embryonic development and assisted reproductive technology (ART). Anti-apoptotic factors in the promotion of early embryonic development, improve embryo quality and ART success rate and other aspects of great significance. The mechanisms of molecular regulation of apoptosis and their inducing factors are summarized, as well as the factors that regulate the expression of apoptotic genes, growth factors, antioxidants, sphingosine-1-phosphate, leptin, prostacyclin, osteopontin and heat shock proteins Research Progress on the Mechanism of Several Important Anti-apoptotic Factors in Promoting Early Embryonic Development.