选用大鼠 2 0只 ,行腹主动脉缩窄 ,建立心肌肥大的动物模型 ,观察心肌组织的形态学变化。结果表明 :线粒体局部或全部空泡化 ,其变异率随着缩窄时间的延长而明显变大。形态计量学分析进一步说明 :实验组线粒体的体积密度、表面积密度和比表面等 3项体视学参数均与对照组有显著差别 ( p <0 .0 1)。前两项随缩窄时间延长而变小 ,后一项则随着缩窄时间延长而变大。结果提示 :线粒体形态改变、体视学指标的变化与心肌损害的程度有着密切的关系 ,故可作为肥大心肌发展中损伤程度的主要客观指标 ,从而为临床诊断、治疗提供实验形态依据 Twenty rats were selected and their abdominal aortic constriction was made to establish an animal model of cardiac hypertrophy. Morphological changes of myocardium were observed. The results showed that mitochondria partially or totally vacuumed, and the variation rate of mitochondria became larger with the extension of the narrowing time. Morphometry analysis further indicated that there were significant differences (p <0.01) in three stereological parameters of mitochondria, such as bulk density, surface area density and specific surface, in the experimental group. The first two become narrower with the narrower time, the latter one becomes larger as the narrower time increases. The results suggest that the change of mitochondrial morphology and the change of stereological index have a close relationship with the degree of myocardial damage, so it can be used as the main objective index of the degree of injury in the development of hypertrophic myocardium, so as to provide experimental morphological basis for clinical diagnosis and treatment