作者报告4例所谓鱼槽肉芽肿的病例,患者发病前均曾接触过热带鱼、金鱼等。4例的皮损均为手指、手背或肘部皮肤发生结节,多发性,类似淋巴管型孢子丝菌病。其中3例结核菌素试验均为阳性。4例活检,组织改变主要为真皮层有上皮样细胞肉芽肿,周围有小圆细胞为主的炎症性细胞浸润,并可见到散在微小脓肿。抗酸染色未查出抗酸菌。将组织碎块接种于小川氏培养基,在27°～30℃避光培养,1～2周后有白色粘液样菌落生长,但将菌落在60°电灯下或室内光曝光1小时后,再避光24小时后菌落变成黄色(光产色试验阳性)。将菌落涂抹标本用抗酸染色后镜检见到比人型结核菌短而稍宽的杆菌,经各种方法检验确定本菌为海鱼分枝杆菌。作者还做了动物接种,并对分离出来的4个菌株做了对各种抗结核药物的敏感试验,结果对利福 The authors report 4 cases of so-called fish tank granuloma, patients had contact with tropical fish, goldfish and so on before the onset. 4 cases of the skin lesions are fingers, nodules on the back of the hand or elbow, multiple, similar lymphatic tube spores filariasis. Three cases of tuberculin test were positive. 4 cases of biopsy, the main tissue changes in the dermis are epithelioid granulomatous cells around the small cell-based inflammatory cell infiltration, and can see scattered tiny abscess. Acid-fast stain did not detect acid-fast bacterium. The tissue fragments were inoculated in Ogawa’s medium and incubated at 27 ° C to 30 ° C in the dark for 1 to 2 weeks followed by white mucoid colony growth. However, after the colonies were exposed to light at 60 ° or room for 1 hour, After 24 hours, the colonies turned yellow (light color test positive). The colony smear specimens with acid-fast staining after microscopy see shorter and slightly longer than the human Mycobacterium tuberculosis, determined by a variety of methods to determine the bacteria Mycobacterium maritima. The authors also did animal vaccination and did a sensitivity test of various anti-TB drugs against the four strains isolated.