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从细胞免疫、体液免疫及郎格罕细胞几个方面综述了红斑狼疮皮肤损害的发生机理。自身抗体及其免疫复合物与红斑狼疮皮损形成有一定关联。抗体依赖细胞的细胞毒性介导了皮肤组织损伤过程。红斑狼疮皮损处T淋巴细胞的明显浸润视为局部炎症反应的重要因素。红斑狼疮皮损表皮郎格罕细胞数目减少,形态异常,提示郎格罕细胞也参与了红斑狼疮皮损形成的病理过程。
The pathogenesis of skin lesions of lupus erythematosus (SLE) was reviewed from the aspects of cellular immunity, humoral immunity and Langerhans cells. Autoantibodies and their immune complexes and lupus erythematosus lesions have a certain relationship. Antibody-dependent cellular cytotoxicity mediates skin tissue damage. The obvious infiltration of T lymphocytes at the lesions of lupus erythematosus is considered as an important factor in the local inflammatory response. Lupus erythematosus lesion epithelial Langerhans cell number decreased, abnormal morphology, suggesting that Langerhans cells are also involved in the pathological process of the formation of lupus erythematosus lesions.