论文部分内容阅读
目的评估小麦纤维素颗粒联合凝结芽孢杆菌活菌片治疗晚期妊娠便秘的临床疗效及安全性。方法选择210例晚期妊娠便秘孕妇,采用随机数字表方法,将孕妇分为三组,分别为小麦纤维素组、益生菌组和联合组,每组70例。小麦纤维素组孕妇给予服用小麦纤维素颗粒(商品名:非比麸),3.5g/次,每天2次,连续服用2周。益生菌组孕妇给予口服凝结芽孢杆菌活菌片,首次2.1g,以后1.05g/次,3次/d,温水送服,连续服用2周。联合组孕妇给予口服凝结芽孢杆菌活菌片和小麦纤维素颗粒(用法同前),连续服用2周。比较三组孕妇治疗前后大便性状评分和每周排便次数,粪便菌群中乳杆菌属、肠球菌属、酵母样真菌变化情况。观察三组孕妇治疗过程中的不良反应。结果联合组孕妇总有效率为91.43%,明显高于益生菌组(84.29%)和小麦纤维素组(82.86%),差异均具有统计学意义(P<0.05)。治疗结束后,联合组孕妇大便性状评分和每周排便次数均优于小麦纤维素组和益生菌组,差异均具有统计学意义(P<0.05);联合组孕妇乳杆菌属和肠球菌属均高于小麦纤维素组和益生菌组,差异均具有统计学意义(P<0.05);联合组孕妇酵母样真菌均低于小麦纤维素组和益生菌组,差异均具有统计学意义(P<0.05)。三组孕妇治疗过程中未出现明显的恶心、呕吐、腹痛、腹泻、过敏等不良反应,治疗期间检测血糖无异常。结论麦纤维素颗粒联合凝结芽孢杆菌活菌片治疗晚期妊娠便秘具有良好的临床疗效,可有效改善孕妇的大便性状和增加排便次数,能有效改善肠道菌群分布,安全性较高,值得临床推广使用。
Objective To evaluate the clinical efficacy and safety of wheat cellulose granules combined with viable Bacillus coagulans tablets in the treatment of congenital constipation in late pregnancy. Methods A total of 210 pregnant women with congenital pregnancy in the second trimester of pregnancy were enrolled in this study. Pregnant women were divided into three groups according to a random number table. They were wheat cellulose group, probiotics group and combination group, with 70 cases in each group. Pregnant women in the wheat cellulose group received wheat cellulose granules (trade name: non-specific bran) at 3.5 g twice daily for 2 weeks. Probiotics group pregnant women given oral Bacillus coagulans live bacteria tablets, the first 2.1g, after 1.05g / time, 3 times / d, warm water delivery, taking 2 consecutive weeks. Pregnant women in the combined group were given oral B. coagulans viable pieces and wheat cellulose granules (used as above) for 2 weeks. The scores of stool traits and number of defecation per week before and after treatment in three groups were compared, and the changes of Lactobacillus, Enterococcus, and yeast-like fungi in the fecal flora were compared. Adverse reactions in the three groups of pregnant women were observed. Results The total effective rate of pregnant women in combination group was 91.43%, which was significantly higher than that in probiotics group (84.29%) and wheat cellulose group (82.86%). The differences were statistically significant (P <0.05). At the end of treatment, the scores of stool traits and weekly bowel movements in pregnant women in combination group were better than those in wheat cellulose group and probiotics group (P <0.05). The lactation genus and enterococci (P <0.05). Compared with wheat cellulose group and probiotics group, the yeast-like fungi in the combination group were significantly lower than those in the wheat cellulose group and the probiotics group (P < 0.05). Three groups of pregnant women did not appear during treatment nausea, vomiting, abdominal pain, diarrhea, allergies and other adverse reactions, no abnormal blood glucose testing during treatment. Conclusions The combination of wheat cellulose granules and Bacillus coagulans viable bacterium tablets in the treatment of congenital constipation of late pregnancy has good clinical curative effect, which can effectively improve the stool characteristics and increase the frequency of defecation in pregnant women, and can effectively improve the distribution of intestinal flora with high safety and worthy of clinical application Promote use.