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目的观察辛伐他汀治疗低氧性肺动脉高压患者的临床疗效。方法58例低氧肺动脉高压患者随机分为治疗组33例,对照组25例。治疗组采用基础治疗+辛伐他汀治疗,对照组采用基础治疗+硝苯地平治疗,两组经4周治疗后测定其肺动脉压、体循环平均压及血气分析,与治疗前作对比,观察治疗前后呼吸困难症状改善的有效率。结果治疗组、对照组静息状态mPAP治疗后较治疗前均有降低趋势,治疗组较对照组改善更为明显。经辛伐他汀治疗后,PaO2也有明显提高,PaCO2有所降低。辛伐他汀治疗组呼吸困难症状改善有效率(63.6%)高于对照组(32.0%)。结论辛伐他汀在治疗低氧性肺动脉高压具有较好的疗效。
Objective To observe the clinical efficacy of simvastatin in patients with hypoxic pulmonary hypertension. Methods Fifty-eight patients with hypoxic pulmonary hypertension were randomly divided into treatment group (n = 33) and control group (n = 25). The treatment group was treated with basic therapy and simvastatin, while the control group was treated with basic therapy and nifedipine. The pulmonary arterial pressure, systemic pressure and blood gas analysis were measured in both groups after 4 weeks of treatment, compared with before treatment, and observed before and after treatment Difficult symptoms improve the efficiency. Results In the treatment group and the control group, mPAP at rest decreased compared with that before treatment, and the improvement in the treatment group was more obvious than that in the control group. After the treatment of simvastatin, PaO2 also increased significantly, PaCO2 decreased. Simvastatin treatment group dyspnea symptom improvement effective rate (63.6%) higher than the control group (32.0%). Conclusion Simvastatin has a good curative effect in treating hypoxic pulmonary hypertension.