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本试验采用麻醉开胸犬经12指肠灌注给予心肌宁药粉,大剂量组1g/kg,小剂量组0.4g/kg,30分钟后可显著降低冠脉阻力,并增加冠脉流量;降低左室内压,左室舒张未期压和±dp/dtmax,增加心输出量、心脏指数和心搏指数,并减少心肌氧利用率和耗氧指数。对心率和心电图无明显影响。综上所述,该药可降低心脏的前后负荷,减少心脏做功,并增加心肌供血,虽然减弱心肌收缩力,但不减少CO,对病毒性心肌炎的心脏具有一定保护作用。
In this study, anesthetic open-chest dogs were given methotrexate powder via 12-intestine infusion, 1 g/kg in the high-dose group and 0.4 g/kg in the low-dose group. After 30 minutes, the coronary resistance was significantly reduced and the coronary flow was increased; Room pressure, left ventricular diastolic pressure and ±dp/dtmax increased cardiac output, heart index and heart rate index, and reduced myocardial oxygen utilization and oxygen consumption index. No significant effect on heart rate and ECG. In summary, the drug can reduce the heart before and after the load, reduce the heart to do work, and increase myocardial blood supply, although the weakening of myocardial contractility, but does not reduce CO, has a protective effect on the heart of viral myocarditis.