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目的 :探讨养心汤对急性心肌梗死经皮冠状动脉介入术(PCI)术后炎症反应及血管内皮功能的影响。方法 :将72例在我院择期行PCI术的急性心肌梗死患者分为研究组和对照组,每组36例。对照组术后给予常规西医对症治疗。研究组在对照组基础上,给予养心汤。对比两组治疗前后炎症反应及血管内皮功能变化情况。记录两组主要心脏不良事件的发生情况。结果 :两组治疗后内皮依赖性血管舒张功能(FMD)、非内皮依赖性血管舒张功能(NMD)均显著升高;研究组治疗后FMD、NMD显著高于对照组治疗后,差异有统计学意义;两组治疗后超敏C反应蛋白(hs-CRP)、肿瘤坏死因子(TNF-a)、白介素6(IL-6)均显著降低;研究组治疗后hs-CRP、TNF-a、IL-6显著低于对照组治疗后,差异有统计学意义;研究组主要心脏不良事件发生率(8.33%)显著低于对照组的(30.56%),差异有统计学意义。结论 :养心汤能显著减轻急性心肌梗死患者PCI术后炎症反应,改善血管内皮功能。
Objective: To investigate the effect of Yangxin Decoction on inflammatory reaction and endothelial function after percutaneous coronary intervention (PCI) in acute myocardial infarction. Methods: 72 patients with acute myocardial infarction undergoing elective PCI during our hospital were divided into study group and control group, with 36 cases in each group. The control group was given conventional Western symptomatic treatment. Study group in the control group, given Yang Xin Tang. Before and after treatment, the inflammatory response and changes of endothelial function were compared. Record the incidence of major cardiac adverse events in both groups. Results: Endothelium-dependent vasodilation (FMD) and non-endothelium-dependent vasodilation (NMD) were significantly increased after treatment in both groups. The FMD and NMD in the study group were significantly higher than those in the control group after treatment The levels of hs-CRP, TNF-a and IL-6 in the two groups were significantly decreased after treatment. The levels of hs-CRP, TNF-a, IL -6 was significantly lower than the control group after treatment, the difference was statistically significant; the incidence of major cardiac adverse events (8.33%) was significantly lower than the control group (30.56%), the difference was statistically significant. Conclusion: Yangxin Decoction can significantly reduce the inflammatory reaction in patients with acute myocardial infarction and improve endothelial function.