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目的 制作稳定的弥漫性脑损伤同时合并局灶性脑损伤动物模型 ,重点探讨其制作方法。方法 将 2 6 6只大鼠分实验组 3组 ,对照组 1组。分别从不同高度打击至 2种不同垫片上 ,观察生命体征及病理学变化。结果 实验组大鼠均有脑弥漫性脑损伤病理改变。打击垫片上加小圆柱组在弥漫性脑损伤同时合并局灶性损伤。有机玻璃管固定 3点 ,重物从 1m高处落下 ,造成的损伤稳定性好。结论 将有机玻璃管固定 3点于墙上 ,打击重锤通过滑轮自 1m高处落下 ,打至置有小钢柱的垫片上 ,能制成稳定、重复性好 ,符合临床颅脑损伤的弥漫性脑损伤同时合并局灶性脑损伤的动物模型。
Objective To make stable diffuse brain injury combined with focal brain injury animal model, focusing on its production method. Methods 2 6 6 rats were divided into experimental group 3 and control group 1. Respectively, from different heights hit two different pads, observed vital signs and pathological changes. Results All rats in the experimental group had diffuse brain injury pathological changes. Combat pad with a small cylinder group in diffuse brain injury with focal lesions. Plexiglass tube fixed 3 points, heavy objects fall from the height of 1m, resulting in good damage stability. Conclusion The plexiglass tube fixed 3 points on the wall, the hammer hit the pulley from 1m height fall, hit the small steel column placed gasket, can be made stable and reproducible, in line with clinical brain injury Animal model of diffuse brain injury with focal brain injury.