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目的探讨T2DM患者血清巨噬细胞抑制因子-1(MIC-1)与颈动脉粥样斑块的相关性。方法根据多普勒超声结果,将113例T2DM患者分为合并颈动脉粥样斑块组(A,n=55)与单纯T2DM组(B,n=58),另选正常对照组(C,n=57)。ELISA测定研究对象血清MIC-1水平。结果 A、B组血清MIC-1水平高于C组(P<0.01),A组高于B组(P<0.01)。相关分析显示,血清MIC-1水平与FPG、HbA1c、SBP、DBP、TG、肿瘤坏死因子α(TNF-α)呈正相关(r=0.183、0.287、0.173、0.194、0.270、0.287,P<0.05),与HDL-C呈负相关(r=-0.410,P<0.01)。多元线性逐步回归分析表明,HbA1c、TG、HDL-C是血清MIC-1水平的独立影响因素(β=0.204、0.176、-0.296,P<0.05)。结论 T2DM患者血清MIC-1水平升高,T2DM合并颈动脉粥样斑块患者血清MIC-1水平较单纯T2DM患者进一步升高。HbA1c、TG、HDL-C是MIC-1的独立相关因素。
Objective To investigate the relationship between serum levels of macrophage inhibitory factor-1 (MIC-1) and carotid artery plaque in T2DM patients. Methods According to the results of Doppler ultrasound, 113 patients with T2DM were divided into three groups: carotid atherosclerotic plaque group (A, n = 55) and simple T2DM group (B, n = 58) n = 57). ELISA test serum MIC-1 level. Results The serum level of MIC-1 in group A and group B was higher than that in group C (P <0.01), and that in group A was higher than that in group B (P <0.01). Correlation analysis showed that serum MIC-1 level was positively correlated with FPG, HbA1c, SBP, DBP, TG and TNF-α (r = 0.183,0.287,0.173,0.194,0.270,0.287, P <0.05) , And negatively correlated with HDL-C (r = -0.410, P <0.01). Multivariate linear stepwise regression analysis showed that HbA1c, TG and HDL-C were the independent influencing factors of serum MIC-1 level (β = 0.204,0.176, -0.296, P <0.05). Conclusions The level of serum MIC-1 in patients with T2DM is elevated. The level of serum MIC-1 in patients with T2DM complicated with carotid atherosclerotic plaque is higher than that in patients with T2DM alone. HbA1c, TG, HDL-C are independent correlates of MIC-1.