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目的:研究西红花酸对小鼠脑缺血再灌注(CIR)损伤的保护作用.方法:采用CIR模型,观察西红花酸对CIR小鼠脑水肿、脑毛细血管通透性及脑组织中乳酸脱氢酶(LDH)、超氧化物歧化酶(SOD)、谷胱苷肽过氧化酶(GSH-Px)活性和丙二醛(MDA)、NO含量的影响.结果:与CIR模型组比较,西红花酸(50、100 mg/kg)连续5 d灌胃能减少CIR小鼠脑组织含水量、伊文思蓝和MDA、NO含量,提高脑组织中LDH、SOD、GSH.Px活性,差异具有统计学意义.结论:西红花酸对小鼠CIR损伤有一定的保护作用,其作用机制可能与西红花酸抗氧化、降低NO含量有关.“,”AIM: To research the protective effects of crocetin on cerebral ischemia-reperfusion (CIR) injury in mice. METHODS: The effects of crocetin on brain edema, brain capillary permeability, the activities of lactate dehydrogenase (LDH), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) in brains and the contents of malondialdehyde (MDA) and nitric oxide (NO) in CIR model mice were observed. RESULTS: Compared with the CIR group, crocetin (50, 100 mg/kg I. G. For 5 d) decreased the content of water, Evans blue, MDA and NO in mice brain tissue, and increased LDH., SOD and GSH-Px activity in brains of CIR mice, with statistical significance. CONCLUSION: Crocetin has protective effects on cerebral isch-emia-reperfusion injury in mice, the mechanism may be related to its anti-oxidative activity and inhibition of NO overproduction.