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脂质代谢异常在肾脏病变进行性恶化机制中起着主要作用。早在 186 0年Ｖｉｒｃｈｏｗ就报道了布赖特病 (Ｂｒｉｇｈｔ’ｓｄｉｓｅａｓｅ)患者的肾脏存在脂肪变性。但直到 1982年 ,Ｍｏｏｒｈｅａｄ等[1] 认为因蛋白尿而致肝脏脂蛋白合成增加可加重肾脏病变 ,有关脂质肾毒性的
Abnormal lipid metabolism plays a major role in the progressive deterioration of renal pathology. Virchow reported the presence of steatosis in the kidneys of patients with Bright’s disease as early as 1860. However, until 1982, Moorhead et al [1] that because of proteinuria caused by increased hepatic lipoprotein synthesis may aggravate renal disease, lipid nephrotoxicity