心血管疾病(cardiac vascular disease,CVD)是慢性肾脏病(chronic kidney disease,CKD)患者死亡的首要原因,血管钙化和CVD发生率、死亡率密切相关~([1])。在未接受透析的CKD 3~5期患者中,血管钙化发生率为30%~65%,而在维持性血液透析人群中高达50%~80%~([2])。CKD时RAS系统激活,Ang II是RAS系统的核心成员,研究发现,Ang II/AT1能促进血管钙 Cardiovascular disease (CVD) is the leading cause of death in patients with chronic kidney disease (CKD), and vascular calcification is closely related to the incidence of CVD and mortality (1). In CKD stage 3-5 patients who did not receive dialysis, the prevalence of vascular calcification was 30% to 65%, whereas in maintenance hemodialysis patients, 50% to 80% (2). RAS system activation in CKD, Ang II is a core member of the RAS system, the study found that Ang II / AT1 can promote vascular calcium