帕金森病(PD)是以黑质多巴胺神经元渐进性减少为病理特征的神经变性疾病,随着病程进展,早期有效的多巴胺能药物会引起运动并发症。为解决这一问题,近十几年来国外多个PD研究中心运用双侧丘脑底核深部电刺激术(STN-DBS)治疗重症PD,研究结果表明STN-DBS是目前公认有效的手术方法 Parkinson’s disease (PD) is a neurodegenerative disease characterized by a gradual reduction in dopaminergic neurons of the substantia nigra as a pathological feature. Early and effective dopaminergic medications can cause motor complications as the course of disease progresses. In order to solve this problem, multiple PD research centers in foreign countries have used double-sided deep brain stimulation of the subthalamic nucleus (STN-DBS) for the treatment of severe PD in recent ten years. The results show that STN-DBS is the accepted and effective surgical method