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目的探讨免疫球蛋白联合甲强龙对重症支原体肺炎患儿T淋巴细胞亚群、免疫球蛋白、补体的影响。方法选择2012年2月-2015年1月东莞市第八人民医院收治的78例重症支原体肺炎患儿为研究对象,采用随机数字表法分为观察组和对照组各39例。对照组患儿给予常规治疗,观察组患儿在常规治疗的基础上给予免疫球蛋白联合甲强龙静脉滴注治疗。观察两组患儿血清T淋巴细胞亚群、免疫球蛋白、补体、临床症状、治疗效果。结果观察组总有效率92.30%,对照组总有效率为71.79%,差异有统计学意义(χ2=11.815,P<0.05);观察组血清CD3、CD4、CD4/CD8水平均明显高于对照组(P<0.05);观察组Ig A、Ig M、Ig G、C3、C4水平均显著低于对照组(P<0.05);观察组热退时间、咳嗽消失时间、啰音消失时间、住院时间均明显短于对照组(P<0.05)。结论免疫球蛋白联合甲强龙治疗有助于缓解重症支原体肺炎患儿炎症状态,改善免疫功能,提高临床治疗效果。
Objective To investigate the effect of immunoglobulin combined with methylprednisolone on T lymphocyte subsets, immunoglobulin and complement in children with severe Mycoplasma pneumoniae. Methods 78 children with severe Mycoplasma pneumoniae admitted to the Eighth People’s Hospital of Dongguan City from February 2012 to January 2015 were selected as the study subjects and divided into observation group and control group with 39 cases in each group by random number table. The control group of children given conventional treatment, observation group of children on the basis of conventional treatment given immunoglobulin combined with methylprednisolone infusion therapy. Serum T lymphocyte subsets, immunoglobulin, complement, clinical symptoms and therapeutic effects were observed in two groups of children. Results The total effective rate was 92.30% in observation group and 71.79% in control group, the difference was statistically significant (χ2 = 11.815, P <0.05). The levels of CD3, CD4 and CD4 / CD8 in observation group were significantly higher than those in control group (P <0.05). The levels of Ig A, Ig M, Ig G, C3 and C4 in the observation group were significantly lower than those in the control group (P <0.05). The observation group’s thermal regression time, cough disappearing time, Were significantly shorter than the control group (P <0.05). Conclusion The combination of immunoglobulin and methylprednisolone can relieve the inflammatory state of children with severe mycoplasma pneumonia, improve the immune function and improve the clinical curative effect.