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在猫上用不同方式升高颅内压,观察脑电图和心电图的变化,结果表明: 1.阶梯性升高颅内压至30—40毫米汞柱时,脑电波频率加快,振幅降低。颅内压升高至50—70毫米汞柱时,以慢波占优势。当颅内压升高接近血压水平时,脑电活动消失。脑电图的变化与脑灌注压有密切关系,除颅内高压可以引起脑灌注压下降外,心脏功能的障碍也可促使血压下降,从而致使脑灌注压降低。 2.急骤升高颅内压至血压的二分之一水平时,如脑灌注压不低于70—80毫米汞柱,脑电图上不出现明显异常。如脑灌注压因血压的下降而迅速降低时,脑电图将出现明显异常,直至脑电波消失。 3.颅内压急骤升高至血压相近水平时,脑电活动在16—17分钟时即发生消失。 4.颅内高压可以引起心率减慢、血压和心电图异常;心电图异常改变可发生在血压异常升高后,也有发生在血压正常时,这可能与心血管中枢的兴奋性改变有关。
In cats with different ways to raise intracranial pressure, EEG and ECG changes were observed, the results showed that: 1. Ladder increased intracranial pressure to 30-40 mm Hg, the brain waves faster frequency, amplitude decreased. Intracranial pressure increased to 50-70 mmHg, the dominant slow-wave. When intracranial pressure rises close to the level of blood pressure, EEG activity disappears. EEG changes and cerebral perfusion pressure are closely related, in addition to intracranial hypertension can cause cerebral perfusion pressure drop, cardiac dysfunction can also promote blood pressure, resulting in decreased cerebral perfusion pressure. 2. Rapid increase in intracranial pressure to one-half the level of blood pressure, such as cerebral perfusion pressure of not less than 70-80 mm Hg, EEG does not appear obvious abnormalities. If the cerebral perfusion pressure drops rapidly due to the drop of blood pressure, the EEG will show obvious abnormalities until the brain waves disappear. 3 sudden increase in intracranial pressure to similar levels of blood pressure, EEG activity disappeared in 16-17 minutes. 4. Intracranial hypertension can cause slow heart rate, abnormal blood pressure and electrocardiogram; ECG abnormal changes can occur after the abnormal increase in blood pressure, also occurred in normal blood pressure, which may be related to changes in the excitement of the cardiovascular center.