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目的:探讨颈动脉内膜-中膜厚度(IMT)增厚和斑块形成的相关危险因素及其与脑梗死之间的关系。方法:应用颈动脉B超技术,对178例意识清晰的脑梗死和非脑血管病住院患者的颈动脉IMT和斑块进行检测。结果:Logistic回归分析发现随着年龄的增大,颈动脉斑块的发生率明显增加(P=0.008)。高血压、糖尿病及血纤维蛋白原水平与颈动脉斑块形成有密切联系(P<0.05)。但是血糖和血脂水平与斑块的形成无明确关系。颈动脉斑块组和非斑块组的吸烟、饮酒、性别和心电图缺血改变无明显差异。脑梗死患者颈动脉斑块的发生率明显增加(P=0.015),颈总、内动脉IMT显著增厚。结论:颈动脉IMT增厚和斑块形成是多因素相互作用的结果,它们是脑梗死的重要危险因素。
Objective: To explore the relationship between carotid intima - media thickness (IMT) thickening and plaque formation risk factors and cerebral infarction. Methods: The carotid artery intima-media thickness (IMT) and plaques in 178 patients with cerebral infarction and non-cerebrovascular disease were detected by carotid artery B-ultrasonography. Results: Logistic regression analysis showed that carotid artery plaque incidence increased significantly with age (P = 0.008). Hypertension, diabetes and fibrinogen levels were closely related to carotid plaque formation (P <0.05). However, there is no clear relationship between the level of blood glucose and blood lipid and the formation of plaque. There were no significant differences in smoking, alcohol consumption, gender and electrocardiographic ischemia between carotid plaque group and non-plaque group. The incidence of carotid plaque was significantly increased in patients with cerebral infarction (P = 0.015), and the IMT in the total and internal carotid arteries was significantly thicker. Conclusions: Carotid IMT thickening and plaque formation are the result of multifactorial interaction. They are important risk factors of cerebral infarction.