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HCV核心蛋白能与胞内多种蛋白相互作用,影响细胞信号转导级联,从而调控NF-κB,AP-1,STAT,E lk-1和SRE等多种转录因子,影响一系列基因的表达。HCV核心蛋白在HCV所致病变的发生机制中起非常重要的枢纽作用。
HCV core protein interacts with many intracellular proteins and affects the signal transduction cascade, which regulates a variety of transcription factors such as NF-κB, AP-1, STAT, E lk-1 and SRE, affecting a series of genes expression. HCV core protein plays a very important pivotal role in the pathogenesis of HCV.