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1973年,Guillemin实验室已分离出生长激素抑制因子(SS)。此前,Krulich等已作了初步研究。由于SS的鉴定和提纯,较大分子的前体是一种28氨基酸多肽,它带有SS-14组成的碳终端。通过免疫细胞化学和放射免疫技术已在神经系统、胃肠道等处找到SS。在人的肠腔内,90%以上的SS免疫活性存在于称为D细胞的粘膜内分泌细胞内。胰腺的SS位于胰岛周围的D细胞。 SS的作用是调节·抑制外分泌、内分泌、旁分泌和自主分泌活性。人体很多器官系统,把它作为广泛的内分泌抑制剂。SS抑制生长激素和生长激素介质C和全部已知的胃肠激素。SS也抑制胃酸分泌、肠吸收,胰碳酸氢盐和淀粉酶分泌,选择性减少狗和人内脏和门脉血流而不影响粘膜血流。SS及其类似物在治
In 1973, Guillemin Labs has isolated growth hormone inhibitory factor (SS). Earlier, Krulich, etc. have made a preliminary study. Due to the identification and purification of SS, the larger molecule precursor is a 28 amino acid polypeptide with a carbon terminal consisting of SS-14. SS has been found in the nervous system, gastrointestinal tract, etc. by immunocytochemistry and radioimmunoassay. In the human intestine, more than 90% of the SS immunoreactivity is present in mucosal endocrine cells called D cells. The pancreatic SS is located in D cells around the islets. The role of SS is to regulate and inhibit exocrine, endocrine, paracrine and autocrine activities. The body many organ systems, as a wide range of endocrine inhibitors. SS inhibits growth hormone and growth hormone mediator C and all known gut hormones. SS also inhibits gastric acid secretion, intestinal absorption, pancreatic bicarbonate and amylase secretion, selective reduction of dog and human visceral and portal blood flow without affecting mucosal blood flow. SS and its analogs under treatment