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5－HT灌流幼年大鼠脑片，66．7％额叶后部ⅣV层神经元由刺激丘脑后腹核引起的EPSPS或EPSCs出现抑制，膜电位和膜电阻无明显改变．此抑制作用为5－HT1B受体激动剂TFMPP和CGS—12066B模拟，被5—HT1A／1B受体拮抗剂pindolol阻抑，但不受其它5－HT亚型受体拮抗剂的影响，5－HT不降低低钙高镁液中外源性谷氨酸引致的去极化反应．上述结果提示，5－HT经突触前膜1B受体抑制神经元间的突触传递。
5-HT perfusion of juvenile rat brain slices, 66.7% of the frontal lamina propria IVV neurons were inhibited by stimulation of the thalamic retroperitoneum EPSPS or EPSCs inhibition, membrane potential and membrane resistance had no significant change. This inhibition was modeled by the 5-HT1B receptor agonist TFMPP and CGS-12066B and was inhibited by the 5-HT1A / 1B receptor antagonist pindolol but not by other 5-HT subtype receptor antagonists. 5- HT does not reduce the depolarization induced by exogenous glutamic acid in low-calcium, high-magnesium solutions. These results suggest that 5-HT pre-synaptic membrane 1B receptor inhibits synaptic transmission between neurons.