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应用放免分析对 2 5例十二指肠溃疡 (DU)和 2 4例慢性胃炎患儿进行空腹血清胃泌素检测 ,并对 15例幽门螺杆菌 (HP)阳性的DU患儿作根治治疗后 ,复查HP及胃泌素 ,并进行对比研究。结果 :HP阳性的DU和慢性胃炎患儿血清胃泌素水平高于HP阴性者 (均P <0 .0 1) ,也高于正常组 (均P <0 .0 5 )。HP根治后患儿血清胃泌素水平较治疗前显著下降 ( (P <0 .0 5 )。提示HP感染与患儿的高胃泌素血症有关 ,是引起上消化道疾病的主要因素之一
Radioimmunoassay (RIA) was used to detect fasting serum gastrin in 25 children with duodenal ulcer (DU) and 24 children with chronic gastritis. Fifteen children with DU positive for Helicobacter pylori (HP) were treated with radical therapy , Review of HP and gastrin, and comparative study. Results: Serum gastrin level was higher in children with HP-positive DU and chronic gastritis than in those with negative HP (all P <0.01) and also higher than those in normal group (all P <0.05). The level of serum gastrin in children with HP after radical reduction was significantly lower than that before treatment (P <0.05), suggesting that HP infection is associated with hypergastrinemia in children and is the main cause of upper gastrointestinal diseases one