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目的:探讨静脉注射乌拉地尔与硝酸甘油微泵对高血压患者拔牙术中血压及心率(HR)的影响。方法:选择自2015年1月到2016年10月在我院进行心电监护拔牙的高血压患者116例纳入本次研究,根据随机数字表法将患者分成观察组以及对照组各58例,对照组给予硝酸甘油加泵静点维持,观察组给予乌拉地尔加泵静点维持,对比两组术前、麻醉时、麻醉后10min、术中及术后10min收缩压(SBP)、舒张压(DBP)以及HR的变化,并对比两组不良反应情况。结果:两组术中及术后10min的SBP和DBP水平均分别明显低于术前,观察组术中的SBP和DBP水平均分别明显低于对照组,差异均有统计学意义(P<0.05);对照组术中及术后10min的HR均明显高于术前,且观察组均明显低于对照组,差异均有统计学意义(P<0.05)。观察组不良反应的总发生率是6.90%(4/58),与对照组的10.34%(6/58)相比,差异无统计学意义(P>0.05)。结论:静脉注射乌拉地尔对高血压患者在拔牙术中血压及HR的影响较小,安全性较好,值得推广。
Objective: To investigate the effect of intravenous injection of urapidil and nitroglycerin on blood pressure and heart rate (HR) in patients with essential hypertension after tooth extraction. Methods: From January 2015 to October 2016, 116 hypertensive patients with ECG extraction and extraction in our hospital were enrolled in this study. According to the random number table, the patients were divided into observation group and control group with 58 cases each. Group was given nitroglycerin plus pump-point maintenance, the observation group was given urapidil plus pump point maintenance, compared two groups before surgery, anesthesia, 10min after anesthesia, intraoperative and postoperative 10min systolic blood pressure (SBP), diastolic blood pressure DBP) and HR changes, and compared two groups of adverse reactions. Results: The SBP and DBP levels in both groups were significantly lower than those before operation at 10min and 10min after operation respectively. The SBP and DBP levels in the observation group were significantly lower than those in the control group (P <0.05, respectively) ). HR in the control group at 10min after operation and at 10min after operation were significantly higher than those before operation, and the observation group were significantly lower than the control group, the difference was statistically significant (P <0.05). The overall incidence of adverse reactions in the observation group was 6.90% (4/58), which was not significantly different from that in the control group (10.34%, 6/58) (P> 0.05). Conclusion: The intravenous injection of urapidil has little effect on the blood pressure and HR during the extraction of hypertension in patients with hypertension, which is safe and worthy of promotion.