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目的:研究鼻咽癌组织中EGFR、C-erbB-2表达特点及其与肿瘤细胞增殖状态的关系。方法:应用免疫组织化学检测鼻咽部32例癌组织、11例慢性炎症黏膜组织中EGFR和C-erbB-2表达情况,同时计数肿瘤细胞PCNA增殖指数。结果:①鼻咽癌组织中EGFR、C-erbB-2蛋白表达阳性率和PCNA增殖指数分别为65.6%、37.5%和(42.5±22.6)%,而在鼻咽部慢性炎症黏膜中表达对应值为9.1%、0%和(10.6±2.2)%,2组间差异均具有统计学意义(P<0.05);②鼻咽癌组织病理学分级与C-erbB-2、EGFR阳性表达率及PCNA指数之间存在正相关;③鼻咽癌组织中C-erbB-2与EGFR表达一致符合率62.5%(20/32),相关系数为0.38(P<0.05),二者共同阳性表达的组织中PCNA指数高于EGFR单阳或双阴组织中的对应值(P<0.01)。结论:C-erbB-2、EGFR在鼻咽癌发生和发展中可起协同作用,二者共同表达与肿瘤细胞增殖活性密切相关。
Objective: To investigate the expression of EGFR and C-erbB-2 in nasopharyngeal carcinoma and their relationship with the proliferation of tumor cells. Methods: Immunohistochemistry was used to detect the expression of EGFR and C-erbB-2 in 32 cases of nasopharyngeal carcinoma and 11 cases of chronic inflammatory mucosa. Meanwhile, the proliferation index of PCNA was counted. Results: (1) The positive rates of EGFR, C-erbB-2 and PCNA in nasopharyngeal carcinoma tissues were 65.6%, 37.5% and 42.5 ± 22.6%, respectively, but not in chronic nasopharyngeal mucosa (9.1%, 0% and (10.6 ± 2.2)%, respectively). There was significant difference between the two groups (P <0.05) .②The positive rate of C-erbB-2 and EGFR in nasopharyngeal carcinoma and PCNA The positive correlation between C-erbB-2 and EGFR expression in nasopharyngeal carcinoma was 62.5% (20/32), the correlation coefficient was 0.38 (P <0.05), and the positive expression of C-erbB- PCNA index was higher than that in EGFR single positive or double negative (P <0.01). Conclusion: C-erbB-2 and EGFR may play synergistic roles in the occurrence and development of NPC. The co-expression of C-erbB-2 and EGFR is closely related to the proliferation of tumor cells.