SDS-聚丙烯酰胺凝胶电泳 ( SDS- PAGE)检测中国眼镜蛇毒蛋白酶水解纤维蛋白原的作用方式 ,发现该蛋白酶可迅速水解纤维蛋白原 Aα链 ,对 γ链作用较弱 ,对 Bβ链无作用 ,是一种新型的α-纤维蛋白原酶 .用比浊法测定血小板聚集率 ,证实中国眼镜蛇毒蛋白酶低剂量 ( 0 .0 2 5mg/kg)、中剂量 ( 0 .0 5mg/kg)以及高剂量 ( 0 .1 mg/kg)体内给药浓度依赖性地抑制 ADP( 1 0 μmol/L)和胶原 ( 1 0 0 mg/L)诱导的兔血小板聚集 SDS-polyacrylamide gel electrophoresis (SDS-PAGE) to detect Chinese cobra venom protease hydrolyzed fibrinogen mode of action and found that the protease can rapidly hydrolyze fibrinogen A α chain, γ chain weak, no effect on B β chain , A new type of α-fibrinogenase, was measured by turbidimetric method to confirm the platelet aggregation rate of Chinese cobra venom at low dose (0. 25mg / kg), medium dose (0. 05mg / kg) High dose (0.1 mg / kg) in vivo dose-dependently inhibited rabbit platelet aggregation induced by ADP (10 μmol / L) and collagen (100 mg / L)