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目的探讨术中射频消融、125I放射性粒子植入联合区域性灌注化疗治疗中晚期胰腺癌的疗效。方法回顾性分析2004年1月～2008年12月我院收治的34例中晚期胰腺癌患者的临床资料,分为2组,实验组16例采用术中射频消融、125I放射性粒子植入联合区域性灌注化疗治疗,对照组18例采用单纯区域性灌注化疗,对比2组患者治疗后疗效、疼痛缓解程度、生存期、不良反应及CA19-9变化。结果实验组治疗有效率(81.25%)高于对照组(27.78%);实验组治疗后CA19-9低于治疗前及对照组;实验组9、12个月生存率及中位生存期高于对照组;实验组比对照组能够明显改善患者的疼痛症状。结论术中射频消融、125I放射性粒子植入联合区域性灌注化疗治疗中晚期胰腺癌可获得较好的疗效。
Objective To investigate the effect of intraoperative radiofrequency ablation and 125I radioactive particle implantation combined with regional perfusion chemotherapy in the treatment of advanced pancreatic cancer. Methods The clinical data of 34 patients with advanced pancreatic cancer who were admitted to our hospital from January 2004 to December 2008 were retrospectively analyzed and divided into two groups. The experimental group received intraoperative radiofrequency ablation and 125I radioactive seed implantation combined with regional radiotherapy In the control group, 18 cases were treated with simple regional perfusion chemotherapy. The curative effect, pain relief degree, survival time, adverse reactions and CA19-9 changes were compared between the two groups. Results The effective rate (81.25%) in the experimental group was higher than that in the control group (27.78%). The CA19-9 in experimental group was lower than that before treatment and control group. The survival rate and median survival time in experimental group at 9 and 12 months were higher than Control group; experimental group than the control group can significantly improve the patient’s pain symptoms. Conclusion Intraoperative radiofrequency ablation, 125I radioactive particle implantation combined with regional perfusion chemotherapy for advanced pancreatic cancer can obtain better curative effect.