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目的探索二甲基甲酰胺(DMF)累积接触量与肝损伤的剂量-反应关系。方法选取6家皮革制造企业847名工人2012年3月—2013年9月期间的职业健康检查资料和历年接触DMF的监测资料,应用Kaplan-Meier法结合三参数Weibull分布拟合的方法,建立DMF累积接触量与肝损伤的剂量-反应关系曲线,并估算出发生肝损伤的DMF累积接触阈值。结果 DFM累积接触量与肝损伤累积发病率的剂量-反应关系曲线为F=1-exp[-0.021×(T-41.3)0.421],发生肝损伤的DMF累积接触阈值为41.3(mg/m3)·月。结论 DMF累积接触量与肝损伤之间存在明显的剂量-反应关系,提示有关部门应采取相关预防控制措施来切实保护作业工人的健康。
Objective To explore the dose-response relationship between cumulative exposure of dimethylformamide (DMF) and liver injury. Methods Occupational health examination data of 847 workers from 6 leather manufacturing enterprises from March 2012 to September 2013 and the monitoring data of exposure to DMF over the years were selected. Kaplan-Meier method and three-parameter Weibull distribution fitting method were used to establish DMF Dose-response curves for cumulative exposure to liver injury and estimate the cumulative contact threshold for DMF with liver injury. Results The dose-response relationship between cumulative contact volume of DFM and cumulative incidence of liver injury was F = 1-exp [-0.021 × (T-41.3) 0.421]. The cumulative contact threshold of DMF with liver damage was 41.3 (mg / m3) ·month. Conclusion There is a significant dose-response relationship between cumulative exposure to DMF and liver injury, suggesting that relevant departments should take relevant preventive and control measures to effectively protect the health of workers.