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胶原病这个概念,1942年由Klemperer作为结缔组织细胞间质的一种系统的变性疾病而提出;另一方面自身免疫概念作为疾病而开始被证明时的Coombs试验,其发现是在1945年,两个概念产生的年代大致相近,二者有着密切的关系,彼此得到了概念的确立和内容的充实,一直发展到现在。即本来作为病理学概念的胶原病,由于高γ-球蛋白血症和多种自身抗体的发现(风湿因子—Waaler 1940,Rose 1948,红斑狼疮因子-Haserick 1950,抗核抗体-Holborow Frion 1957)才逐渐变迁为自身免疫疾病的
The concept of collagen disease was proposed by Klemperer in 1942 as a systemic degenerative disease of connective tissue interstitial cells; on the other hand, the Coombs trial, when the concept of autoimmunity was first documented as a disease, was found in 1945, two Generations of the generation of similar age, the two have a close relationship between the concept of the establishment of each other and the content of enrichment, has been developed until now. That is, collagenopathy, which was originally the concept of pathology, is due to the discovery of hypergammaglobulinemia and a variety of autoantibodies (Rheumatoid factor-Waller 1940, Rose 1948, Lupus erythematosus-Laserick 1950, antinuclear antibody-Halborow Frion 1957) Only gradually transformed into autoimmune diseases