论文部分内容阅读
More than 95％ of Alzheimer’s disease (AD) is late-onset, in which patients show clinical cognition/behavior symptoms after age 65. Unlike early-onset AD that comes with mutations in genes directly involved in amyloid metabolism (APP, PSEN), genetic predispositions associated with late-onset AD are harder to pinpoint, and their mechanistic links to AD development need further investigation.