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目的探讨四联疗法治疗难治性消化溃疡患者的临床疗效。方法 112例难治性消化溃疡患者,将其按照治疗措施的不同分为观察组56例和对照组56例,观察组采用四联疗法治疗,对照组患者采取三联疗法治疗,对比两组患者的治疗效果和幽门螺杆菌根除率。结果观察组治疗总有效率为98.21%,幽门螺杆菌根除率为94.64%;对照组治疗总有效率为62.50%,幽门螺杆菌根除率为46.43%。两组比较差异均有统计学意义(P<0.05)。结论四联疗法治疗难治性消化溃疡患者的临床疗效显著,且幽门螺杆菌的根除率较高,值得在临床上推广使用。
Objective To investigate the clinical effect of quadruple therapy on patients with refractory peptic ulcer. Methods One hundred and twelve patients with refractory peptic ulcer were divided into observation group (56 cases) and control group (56 cases). The observation group was treated with quadruple therapy and the control group was treated with triple therapy. The patients in the two groups were compared Therapeutic efficacy and Helicobacter pylori eradication rate. Results The total effective rate of observation group was 98.21%, and the eradication rate of Helicobacter pylori was 94.64%. The total effective rate of control group was 62.50%, and the eradication rate of Helicobacter pylori was 46.43%. The differences between the two groups were statistically significant (P <0.05). Conclusions The curative effect of quadruple therapy on patients with refractory peptic ulcer is remarkable, and the eradication rate of Helicobacter pylori is high, so it is worth to be popularized in clinic.