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采用免疫组织化学方法和地高辛 -碱性磷酸酶标记原位杂交组织化学方法观察 PTA1在大鼠胸腺、脾脏和淋巴结等淋巴器官中的定位分布。首次证实 PTA1和 PTA1m RNA散在分布于大鼠脾脏和胸腺中 ,但在淋巴结中未见分布。本研究结果为全面了解 PTA1在体内的分布及功能提供重要的实验依据。
Immunohistochemistry and digoxin-alkaline phosphatase-labeled in situ hybridization were used to observe the localization of PTA1 in thymus, spleen and lymph nodes of rats. For the first time, it was confirmed that PTA1 and PTA1mRNA were sporadically distributed in the spleen and thymus of rats but not in lymph nodes. The results of this study provide an important experimental basis for a comprehensive understanding of the distribution and function of PTA1 in vivo.