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目的 观察p53蛋白在成人型及幼儿型复发性呼吸道乳头状瘤病(RRP)初诊病变中的表达与恶变或侵袭发生的关系,探讨其预测个体RRP转归的价值。方法 免疫组化S-P法检测p53蛋白在86例转归不同的RRP中的表达。结果 p53蛋白在AO-RRP及JO-RRP病变中的表达率分别为20.51％和38.29％,统计学分析表明,p53蛋白的表达和发生侵袭或恶变有关(P<0.01)。结论RRP初诊病变中p53蛋白的表达可提示患病个体的转归,即幼儿型RRP易发生侵袭,成人型RRP应密切随访,注意恶变。
Objective To investigate the relationship between the expression of p53 protein and the occurrence of malignant transformation or invasion in adult and juvenile recurrent respiratory papillomatosis (RRP) and to explore its value in predicting the individual RRP outcome. Methods Immunohistochemical S-P method was used to detect the expression of p53 protein in 86 cases of different RRP. Results The expression rates of p53 protein in AO-RRP and JO-RRP lesions were 20.51% and 38.29% respectively. Statistical analysis showed that the expression of p53 protein was associated with invasion or malignancy (P <0.01). Conclusions The expression of p53 protein in newly diagnosed RRP patients may indicate the prognosis of affected individuals, that is, the infantile RRP is prone to invasion, and the adult RRP should be followed up closely and pay attention to malignant transformation.