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本文研究了经r射线照射的小白鼠的全血胆硷酯酶(以下简称ChE)活力和对氯化乙酰胆硷急性毒性的耐受性,並探讨了AET对ChE是否具有保护作用。实验表明,动物在照射后第1,4小时的ChE活力并无显著变化,但在照射后第1天酶活力开始降低,在第3,6,9天酶活力显著降低。照射前注入AET对照射后第3,6,9天的ChE活力具有保护作用,其酶活力与对照动物比较无显著性差異。氯化乙酰胆硷对小白鼠的急性毒性作用试验所得结果与酶活力测定结果平行,照射后第3,6,9天氯化乙酰胆硷的LD_(50)较未照射动物低,但在照射前注入AET,则在照射后第3,6,9天氯化乙酰胆硷的LD_(50)增大。本文讨论了射线照射引起ChE活力降低和AET对ChE活力保护作用的可能机制。
In this paper, we investigated the activity of whole blood cholinesterase (ChE) and acute tolerance to acetylcholine chloride in mice exposed to r-rays and explored whether AET could protect ChE. The experiment showed that there was no significant change in ChE activity at the first and fourth hours after irradiation, but the enzyme activity began to decrease on the first day after irradiation, and the enzyme activity was significantly reduced on the 3rd, 6th and 9th days. Exposure to AET before irradiation on the 3rd, 6th and 9th days after ChE activity has a protective effect, and its enzyme activity compared with the control animals no significant difference. Acetylcholine chloride acute toxicity test in mice and the results obtained by the enzyme activity measured in parallel, the 3rd, 6th and 9th days after exposure to acetylcholine LD_ (50) than non-irradiated animals, but in the irradiation AET before injection, the 3rd, 6th and 9th days after irradiation, the acetylcholine LD_ (50) increased. This article discusses the potential mechanism of radiation-induced reduction of ChE activity and the protective effect of AET on ChE activity.