本文观察了青海高海拔地区（海拔２２６０ｍ～４０００ｍ）五年中胃镜检出的１８３８例消化性溃疡（８７４例胃溃疡和９６４例十二指肠球部溃疡）患者发病与季节的关系。发现消化性溃疡的发病下半年高于上半年，差别有显著性（ｕ＝４．３３，Ｐ＜０．０１）。胃溃疡和十二指肠球部溃疡分别观察，其发病率也是下半年高于上半年，差别有显著性（ｕ＝２．２８，Ｐ＜ｏ．０５；ｕ＝２．０，Ｐ＜０．０５）。 This paper investigates the relationship between the onset of disease and the season in 1838 cases of peptic ulcer (874 cases of gastric ulcer and 964 cases of duodenal ulcer) detected by endoscopy in Qinghai at high altitude (2260m ~ 4000m) over five years. Found that the incidence of peptic ulcer in the second half is higher than the first half, the difference was significant (u = 4.33, P <0.01). Gastric ulcer and duodenal ulcer were observed, the incidence was also higher in the second half than the first half, the difference was significant (u = 2.28, P <0.05; u = 2.0, P <0 .05).