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目的探讨热休克蛋白70(HSP70)与宫颈尖锐湿疣(CA)和鳞癌发病的关系。方法应用免疫组织化学S-P法检测40例宫颈CA、40例宫颈鳞癌及10例正常宫颈组织中HSP70的表达。结果HSP70在宫颈鳞癌、宫颈CA、正常宫颈组织中的阳性表达率分别为70%、50%、20%,宫颈鳞癌显著高于正常宫颈、宫颈CA,差异有统计学意义(均P<0.05);且与宫颈鳞癌临床分期、有无淋巴结转移呈正相关(均P<0.05)。结论HSP70在宫颈鳞癌中高表达,提示HSP70可能参与了宫颈病变过程。
Objective To investigate the relationship between heat shock protein 70 (HSP70) and cervical condyloma acuminatum (CA) and squamous cell carcinoma. Methods Immunohistochemical S-P method was used to detect the expression of HSP70 in 40 cases of cervical CA, 40 cases of cervical squamous cell carcinoma and 10 cases of normal cervical tissue. Results The positive expression rates of HSP70 in cervical squamous cell carcinoma, cervical CA and normal cervical tissue were 70%, 50% and 20% respectively. The positive rate of HSP70 in cervical squamous cell carcinoma was significantly higher than that in normal cervix and cervical cervix (all P < 0.05). There was a positive correlation between clinical stage and lymph node metastasis (all P <0.05). Conclusion HSP70 is highly expressed in cervical squamous cell carcinoma, suggesting that HSP70 may be involved in cervical lesions.