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对288例肌注林可霉素患者的局部ADR进行集中监测,19例出现ADR,发生率为6.6％。四种肌注林可霉素给药方案的ADR发生率为:(1)年龄≥14岁组:方案Ⅰ:0.6g/次,(30％—2mL/次)共101例,发生率14.8％;方案Ⅱ:0.6g/次(10％—6mL或12％—5mL/次)52例,发生率1.9％;(2)年龄<14岁组:方案Ⅲ:10mg/(kg·次),90例,发生率0％;方案Ⅳ:15mg/(kg·次),45例,发生率6.7％。19例ADR表现为红、肿、热、痛局部反应。19例ADR平均程度分、出现时间及持续时间分别为4.4±1.8分,2.2±0.7d及4.1±2.1d。
A total of 288 patients with intramuscular injection of lincomycin were monitored for local ADR, and 19 patients developed ADR, with an incidence of 6.6%. The incidence of ADR in the four intramuscular injection of lincomycin was: (1) 101 cases of age≥14 years old (Ⅰ: 0.6g / time, 30% -2mL / time), the incidence rate was 14.8% ; Program Ⅱ: 0.6g / time (10% -6mL or 12% -5mL / time) 52 cases, the incidence of 1.9%; (2) age <14 years old group: program Ⅲ: 10mg / (kg · times), 90 Cases, the incidence of 0%; program Ⅳ: 15mg / (kg · times), 45 cases, the incidence of 6.7%. 19 cases of ADR showed red, swollen, hot, painful local reactions. The average ADR scores of 19 patients were 4.4 ± 1.8 points, 2.2 ± 0.7 days and 4.1 ± 2.1 days respectively.