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在严重血脂异常患者中,有一部分是由基因异常引起的。基因异常引起的血脂异常患者的特点是血脂异常严重、动脉粥样硬化和冠心病发生早、心血管事件发生率高。基因异常导致血脂异常主要通过影响低密度脂蛋白受体、载脂蛋白B、9型前蛋白转化酶枯草杆菌蛋白酶/Kexin等起作用。基因异常引起的血脂异常的治疗包括他汀类药物、胆固醇吸收抑制剂、脂蛋白采集术、米泊美生、洛美他派、9型前蛋白转化酶枯草杆菌蛋白酶/Kexin抑制剂。
In severe dyslipidemia patients, some are caused by genetic abnormalities. Patients with dyslipidemia caused by genetic abnormalities are characterized by severe dyslipidemia, early occurrence of atherosclerosis and coronary heart disease, and high incidence of cardiovascular events. Gene abnormalities lead to dyslipidemia mainly by affecting the low density lipoprotein receptor, apolipoprotein B, type 9 preproteolytic enzyme subtilisin / Kexin play a role. Treatment of dyslipidemia caused by genetic abnormalities includes statins, cholesterol absorption inhibitors, lipoprotein collection, mometasone, Limethata, type 9 proprotein convertase subtilisin / Kexin inhibitors.