论文部分内容阅读
基于Cyclofenil对雌激素β受体的选择性结合能力,完成了用于乳腺癌单光子发射计算机断层成像(SPECT)显像的新型聚乙二醇(PEG)-cyclofenil分子探针前体的合成,并用99mTc对该前体进行放射化学标记.Cyclofenil的PEG修饰作为整个合成过程的关键步骤,反应快速高效,产率高达98%,可在30 min内反应完全.整个合成过程在较温和的反应条件下完成,具有高产率、速度快的特点,该实验为放射性标记试验及micro-SPECT成像奠定了良好的基础.
Based on the selective binding ability of Cyclofenil to the estrogen beta receptor, a novel PEG-cyclofenil molecular probe precursor for the single photon emission computed tomography (SPECT) imaging of breast cancer was completed, And radiochemical labeling of the precursor with 99mTc.Cyclofenil PEG as a key step in the synthesis process, the reaction is fast and efficient, the yield was as high as 98%, the reaction can be completed within 30 min.The entire synthesis process under milder reaction conditions With high yield and high speed. The experiment lays a good foundation for radiolabeling test and micro-SPECT imaging.