宫内生长迟缓(intrauterine growth restriction,IUGR)可通过“编程机制”对机体各器官功能产生长期乃至终生影响,与成年期危害人类健康的许多发展中疾病如高血压、冠心病、糖尿病、慢性肾脏病等均有一定关系[1-3]。越来越多的人体和动物实验证明,胚胎发育的初期环境尤其是营养因素在其中发挥了重要的作用。从分子机制角度来说,这种发生于生命初期的营养不良为成年后疾病 Intrauterine growth restriction (IUGR) can have long-term and even lifelong effects on various organ functions in the body through the “programming mechanism.” Many of the developing diseases endangering human health in adulthood such as hypertension, coronary heart disease, diabetes, Chronic kidney disease have a certain relationship [1-3]. More and more human and animal experiments prove that the initial environment of embryo development, especially nutrition, plays an important role. From a molecular point of view, this type of malnutrition, which occurs early in life, is an adult disease